Borussia Dortmund eliminated Benfica in the 1963/64 European Cup first round, their only previous encounter. They lost 2-1 in the first leg, but won 5-0 in Germany to win the tie.
Benfica have won only one of their last 15 European Cup/Champions League encounters with German clubs (D5 L9), it was against Kaiserslautern in November 1998.
Benfica have reached the knockout stages of the Champions League for the second season in a row – this hadn’t happened before for the Lisbon side.
Borussia Dortmund have qualified for the Champions League knockout stages in each of their last four participations, finishing top on each occasion.
Borussia Dortmund are one of six teams yet to suffer a defeat in the Champions League this season (W4 D2). They won both games earlier this season against another Lisbon side, Sporting (2-1 in Portugal, 1-0 at home).
However, Dortmund have lost six of their last eight games in the Champions League knockout stages (W2).
Meanwhile, Benfica have lost only one of their seven home games in the Champions League knockout stages (W3 D3), it was against Chelsea in March 2012 (0-1).
Borussia Dortmund scored 21 goals in the group stages this season, the record in a Champions League group campaign, whilst Benfica conceded 10 goals, the joint-highest tally among teams left in the competition.
Eduardo Salvio has scored three and assisted two of Benfica’s last eight Champions League goals.
Pierre-Emerick Aubameyang has scored in all four of his Champions League starts this season (4 goals) whilst teammate Marco Reus has scored 10 goals and delivered four assists in his last 11 Champions League games.